Tricyclic compounds and uses thereof
US6723736B2 · kind B2 · utility
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22References
43Claims
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Key dates
| Filing date | Oct 10, 2001 |
| Grant date | Apr 20, 2004 |
| Priority date | — |
| Expiry date | Oct 10, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D311/76
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Substituted isoquinolines, isochromanones and isothiochromanones that inhibit the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and/or interleukin-6 (IL-6) and/or the enzyme cyclooxygenase-2 (COX-2) and/or interleukin-10 (IL-10). Compositions containing such compounds and methods of using such compounds for treatment and/or prevention of inflammation, inflammatory diseases, immunologic diseases and other diseases mediated by TNF-alpha, IL-6, COX-2 and/or IL-10 are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.