Papillomavirus polyprotein constructs

US6726912B1 · kind B1 · utility

Assignees

• CSL LIMITED · AU
• The University of Queensland St. Lucia · AU

Inventors

• Elizabeth Ann Webb · Melbourne, AU
• Mary Brigid Margetts · Melbourne, AU
• John C. Cox · Gisborne, AU
• Ian Frazer · Brisbane, AU
• Nigel Alan John McMillan · Brisbane, AU
• Mark Philip Williams · Brisbane, AU
• Margaret Bridget Holland Moloney · Melbourne, AU
• Stirling John Edwards · Melbourne, AU

Key dates

• Filing date: Dec 11, 2001
• Grant date: Apr 27, 2004
• Expiry date: Dec 12, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2710/20022
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A papillomavirus polyprotein construct comprises at least two amino acid sequences fused directly or indirectly together, each of the sequences being the sequence of an early ORF protein of papillomavirus or an immunogenic variant or fragment thereof, and at least one of said sequences being other than the E6 or E7 protein sequence or an immunogenic variant or fragment thereof. Nucleic acid molecules encoding the polyprotein construct, prophylactic or therapeutic compositions comprising the polyprotein construct or the nucleic acid molecule, and methods for eliciting an immune response against papillomavirus in a host animal are also provided.