Alzheimer's disease secretase, APP substrates therefor, and uses therefor
US6727074B2 · kind B2 · utility
20Cited by
24References
26Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 27, 2001 |
| Grant date | Apr 27, 2004 |
| Priority date | — |
| Expiry date | Feb 27, 2021 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/96472
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides the enzyme and enzymatic procedures for cleaving the &bgr; secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.