Inhibitors of bacterial NAD synthetase

US6727237B2 · kind B2 · utility

Inventors

• Wayne J. Brouillette · Pelham, US
• Donald D. Muccio · Hoover, US
• Mark J. Jedrzejas · Pelham, US
• Christie G. Brouillette · Pelham, US
• Yancho Devedjiev · Charlottesville, US
• Walter Cristofoli · Birmingham, US
• Lawrence J. DeLucas · Birmingham, US
• Jose Gabriel Garcia · Munich, DE
• Laurent Schmitt · Igny, FR
• Sadanadan E. Velu · Birmingham, US

Key dates

• Filing date: Oct 25, 2002
• Grant date: Apr 27, 2004
• Expiry date: Oct 25, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C40B40/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides methods of synthesizing and screening inhibitors of bacterial NAD synthetase enzyme, compounds thereof, and methods of treating bacterial and microbial infections with inhibitors of bacterial NAD synthetase enzyme.