Benzofurazan compounds which enhance AMPA receptor activity

US6730677B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Gary A. Rogers · Basseterre, KN
• Christopher Marrs · Rancho Palos Verdes, US

Key dates

• Filing date: Apr 27, 2001
• Grant date: May 4, 2004
• Expiry date: Apr 27, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of general structural formula (1) are shown to have AMPA receptor enhancing properties. The compounds are useful for such therapeutic purposes as facilitating the learning of behaviors dependent upon AMPA receptors, and in treating conditions, such as memory impairment, in which AMPA receptors, or synapses utilizing these receptors, are reduced in numbers or efficiency. They may also be used to enhance excitatory synaptic activity in order to restore an imbalance between brain subregions, as in treatment of schizophrenia or schizophreniform behavior.