Benzoylguanidine salt and hydrates thereof

US6730678B2 · kind B2 · utility

Assignee

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

• Christian Eickmeier · Mittelbiberach, DE
• Peter Sieger · Mittelbiberach, DE
• Werner Rall · Mittelbiberach, DE
• Volkmar Koerner · Nordenham, DE
• Rolf Herter · Schwabach, DE

Key dates

• Filing date: Jan 25, 2002
• Grant date: May 4, 2004
• Expiry date: Jan 25, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D207/416
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

4-[4-(2-pyrrolylcarbonyl)-1-piperazinyl]-3-trifluoromethylbenzoylguanidine hydrochloride and its hydrates, processes for preparing this benzoylguanidine salt and its hydrates, pharmaceutical compositions containing this benzoylguanidine salt and its hydrates, and its use in treating diseases, particularly those in which inhibition of the cellular Na+/H+ exchange is of therapeutic benefit.