Patent · US Expired

11-&bgr;-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia

US6730690B2 · kind B2 · utility

20Cited by

0References

42Claims

0Family size

Assignee

MERCK & CO., INC. · US

Inventors

Steven H. Olson · Millbrae, US
James M. Balkovec · North Plainfield, US
Yuping Zhu · Edison, US

Key dates

Filing date	Jun 9, 2003
Grant date	May 4, 2004
Priority date	—
Expiry date	Jun 9, 2023

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P43/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Compounds having Formula I, including pharmaceutically acceptable salts, hydrates and solvates thereof: are selective inhibitors of the 11&bgr;-HSD1 enzyme. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dylsipidemia, hyperlipidemia, hypertension, Syndrome X, and other symptoms associated with NIDDM.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.