Induction of cytotoxic T-lymphocyte responses
US6733763B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 20, 2000 |
| Grant date | May 11, 2004 |
| Priority date | — |
| Expiry date | Dec 20, 2020 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and compositions useful for inducing a cytotoxic T lymphocyte response (CTL) in a human or domesticated or agriculturally important animal. The method includes the steps of providing the antigen to which the CTL response is desired and providing a microfluidized antigen formulation which comprises, consists, or consists essentially of two or more of a stabilizing detergent, a micelle-forming agent, and an oil. This antigen formulation is preferably lacking in an immunostimulating peptide component, or has sufficiently low levels of such a component that the desired CTL response is not diminished. This formulation is provided as a stable oil-in-water emulsion.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.