Multiparticulate bisoprolol formulation

US6733789B1 · kind B1 · utility

Assignee

• BIOVAIL LABORATORIES · KN

Inventors

• Paul Stark · Bowling Green, US
• Catherine Mary Kelly · Athlone, IE
• Niall Fanning · Athlone, IE

Key dates

• Filing date: Jan 20, 2000
• Grant date: May 11, 2004
• Expiry date: Jan 20, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/5026
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A multiparticulate bisoprolol formulation for once-daily oral administration, each particle of which comprises a core of bisoprolol or a pharmaceutically acceptable salt thereof surrounded by a polymeric coating, the polymeric coating being effective to achieve an initial lag of bisoprolol release in vivo of at least 4-6 hours following administration and thereafter maintaining therapeutic concentrations of bisoprolol for the remainder of the twenty-four hour period. The formulation can be used for night-time dosing so as to minimize the likelihood of acute cardiovascular occurrences in the well-documented high risk period in the morning.