Methods for the identification of inhibitors of 3-isopropylmalate dehydratase as antibiotics
US6733963B2 · kind B2 · utility
0Cited by
8References
4Claims
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Assignee
Inventors
Key dates
| Filing date | Dec 6, 2001 |
| Grant date | May 11, 2004 |
| Priority date | — |
| Expiry date | Dec 6, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/18
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present inventors have discovered that 3-Isopropylmalate dehydratase is essential for fungal pathogenicity. Specifically, the inhibition of 3-Isopropylmalate dehydratase gene expression in fungi results in no signs of successful infection or lesions. Thus, 3-Isopropylmalate dehydratase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit 3-Isopropylmalate dehydratase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.