Method for identifying an agent that affects a hedgehog signaling pathway
US6733971B2 · kind B2 · utility
0Cited by
4References
33Claims
0Family size
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Key dates
| Filing date | Aug 21, 2001 |
| Grant date | May 11, 2004 |
| Priority date | — |
| Expiry date | Aug 21, 2021 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides transcription factors associated with the hedgehog signaling pathway that are regulated by dephosphorylation by phosphatases. Hedgehog response elements (HRE) that interact with the dephosphorylated transcription factors are also provided as well as methods for identifying compounds that are phosphatase inhibitors. Methods of treating tumors in a subject by modulating the phosphorylation of the transcription factor are also included.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.