Method for re-sensitizing vancomycin resistant bacteria which selectively cleave a cell wall depsipeptide
US6734165B2 · kind B2 · utility
4Cited by
7References
73Claims
0Family size
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Key dates
| Filing date | Aug 23, 2001 |
| Grant date | May 11, 2004 |
| Priority date | — |
| Expiry date | Aug 23, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates a method for re-sensitizing vancomycin resistant Gram-positive bacteria in which resistance results from the conversion of an amide bond to an ester bond in the cell wall peptide precursors of the bacteria which comprises using an antibacterial amount of vancomycin or a homolog of vancomycin and an amount of an agent effective to selectively cleave the ester bond so as to thereby re-sensitize vancomycin resistant bacteria.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.