Exo-S-mecamylamine formulation and use in treatment

US6734215B2 · kind B2 · utility

Assignee

• University of South Florida · US

Inventors

• Douglas Shytle · Lutz, US
• Paul R. Sanberg · Spring Hill, US
• Mary Newman · Valrico, US
• Archie A. Silver · Tampa, US

Key dates

• Filing date: Jun 15, 2001
• Grant date: May 11, 2004
• Expiry date: Aug 24, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C211/38
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Medical conditions are treated by administering a therapeutically effective amount of exo-S-mecamylamine or a pharmaceutically acceptable salt thereof, substantially free of its exo-R-mecamylamine, said amount being sufficient to ameliorate the medical condition. The medical conditions include substance addiction (involving nicotine, cocaine, alcohol, amphetamine, opiate, other psychostimulant and a combination thereof), Tourette's Syndrome, and neuropsychiatric disorders (such as bipolar disorder, depression, an anxiety disorder, schizophrenia, a seizure disorder, Parkinson's disease and attention deficit hyperactivity disorder).