Biosensor electrode mediators for regeneration of cofactors and process for using
US6736957B1 · kind B1 · utility
364Cited by
5References
20Claims
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Key dates
| Filing date | Jun 7, 2000 |
| Grant date | May 18, 2004 |
| Priority date | — |
| Expiry date | Jun 7, 2020 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T29/49155
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention is based on the discovery of NAD+ and NADP+ mediator compounds that do not bind irreversibly to thiol groups in the active sites of intracellular dehydrogenase enzymes. Such mediator compounds avoid a common mode of enzyme inhibition. The mediators can therefore increase the stability and reliability of the electrical response in amperometric electrodes constructed from NAD- or NADP-dependent enzymes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.