Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging
US6737038B1 · kind B1 · utility
16Cited by
4References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 17, 2000 |
| Grant date | May 18, 2004 |
| Priority date | — |
| Expiry date | May 17, 2020 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/2821
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
This invention relates to a novel method of screening for inhibitors of beta-amyloid production, and thereby identifying such inhibitors as therapeutics for neurological and other disorders involving APP processing and beta-amyloid production. This invention also relates to identifying macromolecules involved in APP processing and beta-amyloid production. Furthermore, inhibitors identified by the screening method of the present invention are useful in the treatment of neurological disorders, such as Alzheimer's disease, which involve elevated levels of A&bgr; peptides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.