Methods for screening GABA-modulatory compounds for specified pharmacological activities
US6737242B1 · kind B1 · utility
1Cited by
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12Claims
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Key dates
| Filing date | May 5, 2000 |
| Grant date | May 18, 2004 |
| Priority date | — |
| Expiry date | May 5, 2020 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods are provided that are useful in assaying compounds for cognitive enhancing properties, anxiolytic properties, hypnotic properties, or antidepressant properties. These methods involve determining the in vitro efficacy and EC50 of the compounds at defined series of cloned GABAA subtype receptors composed of specific variants of &agr;,&bgr;, and &ggr; subunits in order to develop and an activity profile for each compound. Optionally, the binding affinities of the compounds at GABAA receptors are also determined. As an additional step the in vivo effects of the compounds may be tested in animal models.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.