Patent · US Expired

Overcoming DAPA aminotransferase bottlenecks in biotin vitamers biosynthesis

US6737256B2 · kind B2 · utility

0Cited by

4References

22Claims

0Family size

Assignee

Roche Vitamins Inc. · US

Inventors

Scott Van Arsdell · Lexington, US
R. Rogers Yocum · Lexington, US
John B. Perkins · Reading, US
Janice G. Pero · Lexington, US

Key dates

Filing date	Jul 14, 1997
Grant date	May 18, 2004
Priority date	—
Expiry date	Sep 5, 2017

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12R2001/125
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

A method is disclosed for the increased production of biotin and the biotin precursor dethiobiotin using a bacterium that produces a lysine-utilizing DAPA aminotransferase. This method involves the use of a bacterium that is either grown in the presence of lysine or deregulated for lysine biosynthesis.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.