Method for generating genetically altered antigens
US6737268B1 · kind B1 · utility
5Cited by
8References
10Claims
0Family size
Assignee
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Key dates
| Filing date | Nov 14, 2000 |
| Grant date | May 18, 2004 |
| Priority date | — |
| Expiry date | Nov 14, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/1024
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and animal varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of mutation. These methods are useful for generating genetic diversity within genes encoding for therapeutic antigens to produce altered polypeptides with enhanced antigenic and immunogenic activity. Moreover, these methods are useful for generating effective vaccines.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.