Methods for modulation of oocyte activation
US6737272B2 · kind B2 · utility
4Cited by
3References
6Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Dec 8, 2000 |
| Grant date | May 18, 2004 |
| Priority date | — |
| Expiry date | Dec 8, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/22
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Nitric oxide synthase and nitric-oxide-related bioactivity are shown to be necessary and sufficient for activation of an oocyte during the process of fertilization. Methods are provided for the modulation of oocyte activation through modulation of nitric oxide levels. Oocyte activation is enhanced by the addition of nitric oxide synthase, nitric oxide synthase activators, nitric oxide donors, or other compounds that increase the nitric oxide levels of the oocyte during fertilization. The administration of NOS inhibitors is used to block oocyte activation, where contraception is desired.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.