Method of preparing fetuin to induce apoptosis
US6737402B2 · kind B2 · utility
1Cited by
10References
9Claims
0Family size
Inventor
Key dates
| Filing date | Jul 9, 2001 |
| Grant date | May 18, 2004 |
| Priority date | — |
| Expiry date | Nov 12, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/71
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides for an improved method of preparing fetuin by using a chelating agent to remove inorganic ions, such as zinc, calcium, and barium, from fetuin. Then, reloading the “naked” fetuin with Zinc Acetate to form a product that is mainly Fetuin-Zinc. This improved method of preparing Fetuin-Zinc or supercharged zinc fetuin increases the effectiveness of inducing apoptosis in cancer cells by three to four times.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.