Methods of using analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamate 89, aspartate 101 or leucine 137
US6737404B2 · kind B2 · utility
4Cited by
37References
30Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 5, 2001 |
| Grant date | May 18, 2004 |
| Priority date | — |
| Expiry date | Apr 5, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to novel muteins of human basic fibroblast growth factor with superagonist properties. Both protein and the respective encoding nucleic acid species are disclosed. The invention also embodies vectors and host cells for the propagation of said nucleic acid sequences and the production of said muteins. Also disclosed are methods for stimulating cell division, treating a wound, treating ischemia, treating heart disease, treating neural injury, treating peripheral vascular disease, treating a gastric ulcer and treating a duodenal ulcer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.