Stabilized protein preparation and process for its preparation

US6737405B2 · kind B2 · utility

Assignee

• Aventis Behring GmbH · DE

Inventors

• Juergen Roemisch · Marburg, DE
• Harald Stauss · Steffenberg, DE
• Hans-Arnold Stoehr · Wetter, DE

Key dates

• Filing date: May 7, 2001
• Grant date: May 18, 2004
• Expiry date: May 7, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/26
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A stabilized protein preparation is described which contains no antithrombin III and is protected against loss of activity during pasteurization by the addition of stabilizers which comprise one or more saccharides as a mixture with more than 0.5 mol/l of one or more amino acids chosen from the group arginine, lysine, histidine, phenylalanine, tryptophan, tyrosine, aspartic acid and its salts or glutamic acid and its salts. Glycine and/or glutamine can also be additionally added to each of these amino acids. A process for the viral inactivation or viral depletion of a protein preparation of this type which contains the abovementioned stabilizers and is subjected to pasteurization or viral depletion by filtration, centrifugation or treatment with detergents or bactericidal or virucidal agents is also described.