Patent · US Expired

Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and the use thereof

US6737418B2 · kind B2 · utility

81Cited by

8References

39Claims

0Family size

Assignee

Euro-Celtique S.A. · LU

Inventors

Derk Hogenkamp · Carlsbad, US
Ravindra B. Upasani · San Jose, US
Phong X. Nguyen · Placentia, US

Key dates

Filing date	Apr 30, 2002
Grant date	May 18, 2004
Priority date	—
Expiry date	Apr 30, 2022

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D403/04
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

This invention relates to compounds having the Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Het and R5-R13 are set in the specification. The invention also is directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.