Cyclo-alkyl substituted benzimidazoles and their use as PARP inhibitors

US6737421B1 · kind B1 · utility

Assignee

• Abbott GmbH & Co. KG · DE

Inventors

• Wilfried Lubish · Heidelberg, DE
• Michael Andreas Kock · Schifferstadt, DE
• Thomas Hoeger · Edingen-Neckarhausen, DE
• Roland Grandel · Dossenheim, DE
• Sabine Schult · Speyer, DE
• Reinhold Mueller · Schifferstadt, DE

Key dates

• Filing date: Apr 4, 2002
• Grant date: May 18, 2004
• Expiry date: Apr 4, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula I or II and their tautomeric forms, possible enantiomeric and diastereomeric forms, possible cistrans isomers on the rings in A and prodrugs thereof, pharmaceutical compositions containing these compounds and methods of treating neurodegenerative diseases or neuronal damage with these compounds.