Sulfonyloxazoleamines

US6737426B1 · kind B1 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Rolf Gericke · Seeheim-Jugenheim, DE
• Henning Bottcher · Darmstadt, DE
• Michael Gassen · Munich, DE
• Hartmut Greiner · Darmstadt, DE

Key dates

• Filing date: May 28, 2002
• Grant date: May 18, 2004
• Expiry date: May 28, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to compounds of the general formula (I) whereR1 and R2 independently of one another are H, —R6, C3-C8-cycloalkyl, —(CH2)n—R7, —(CH2)n—O—R6, —(CH2)n—NH2, —(CH2)n—NHR6, —(CH2)—N(R6)2, C2-C6-alkenyl or, where appropriate, together form a mononuclear saturated heterocycle having one or two nitrogen, oxygen and/or sulfur atoms,R3 and R4 independently of one another are H, —R6, —CF3, —NO2, —Hal, —OH, —O—R6, —NH2, —NH—R6 or —N(R6)2,R5 is a 5- or 6-membered, saturated or unsaturated heterocycle having one or two nitrogen, oxygen and/or sulfur atoms which may be mono- or disubstituted by R6, —CF3, —NO2, —Hal, —OH, —O—R6, —NH2, —NH—R6 or —N(R6)2, andR6 is C1-C6-alkyl,R7 is R3- and/or R4-substituted phenyl,n is 0 to 2,and physiologically acceptable salts or solvates thereof.The invention also relates to the use of the compounds of the general formula I as medicaments.