Pyrrole derivatives as phosphodiesterase VII inhibitors

US6737436B1 · kind B1 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Hans-Michael Eggenweiler · Darmstadt, DE
• Rochus Jonas · Darmstadt, DE
• Michael Wolf · Darmstadt, DE
• Michael Gassen · Munich, DE
• Thomas Welge · Alsbach, DE

Key dates

• Filing date: May 3, 2002
• Grant date: May 18, 2004
• Expiry date: May 12, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula I in whichR1 and R2, independently of one another, each denote H, A, OA, SA or HaI,R3 denotes H or A,R4 denotes A or NH2,R5 denotes H, NH2, NHA or NA2,A denotes alkyl having 1 to 10 carbon atoms, alkenyl, cycloalkyl or alkylenecycloalkyl,Hal denotes F, Cl, Br or I,and their physiologically acceptable salts and/or solvates, as phosphodiesterase VII inhibitors.