Synthesis and antimicrobial activity of novel dicationic “reversed amidines”

US6737440B2 · kind B2 · utility

Assignees

• The University of North Carolina at Chapel Hill · US
• Georgia State University Research Foundation · US
• Duke University · US

Inventors

• David W. Boykin · Atlanta, US
• Richard R. Tidwell · Pittsboro, US
• W. David Wilson · Atlanta, US
• John Perfect · Durham, US
• Chad Stephens · Villa Rica, US

Key dates

• Filing date: Nov 6, 2001
• Grant date: May 18, 2004
• Expiry date: Nov 6, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to novel 2,5-bis {[alkyl(or aryl)imino]aminophenyl}furans and thiophenes of the general formula in which R1, R2, R3 and R4 are each independently selected from the group consisting of H, alkyl, alkoxy, halide, and alkylhalide groups; R5 is H, alkyl or aryl; R6 is H, alkyl, aryl, or NR7R8, in which R7 and R8 are each independently selected from the group consisting of H, alkyl and aryl; and X is O, S or NR9, in which R9 is H or alkyl, and to the use of such compounds.