Nitric oxide-modified linear poly(ethylenimine) fibers and uses thereof
US6737447B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | May 16, 2000 |
| Grant date | May 18, 2004 |
| Priority date | — |
| Expiry date | May 16, 2020 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/2998
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A novel coating for medical devices provides nitric oxide delivery using nanofibers of linear poly(ethylenimine)diazeniumdiolate. Linear poly(ethylenimine)diazeniumdiolate releases nitric oxide (NO) in a controlled manner to tissues and organs to aid the healing process and to prevent injury to tissues at risk of injury. Electrospun nano-fibers of linear poly(ethylenimine) diazeniumdiolate deliver therapeutic levels of NO to the tissues surrounding a medical device while minimizing the alteration of the properties of the device. A nanofiber coating, because of the small size and large surface area per unit mass of the nanofibers, provides a much larger surface area per unit mass while minimizing changes in other properties of the device.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.