Inclusion complees of a high potent opioid peptide, pharmaceutical compositions and method of treatment

US6740639B1 · kind B1 · utility

Assignee

• COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH · IN

Inventors

• Anil Kumar Dwivedi · Lucknow, IN
• Madhu Khanna · Lucknow, IN
• Wahajul Haq · Lucknow, IN
• Ram Raghubir · Lucknow, IN
• Sudhir Srivastava · Eindhoven, NL
• Puvvada Murthy · Lucknow, IN
• Onkar Prasad Asthana · Lucknow, IN
• Jagdishwar Sahay Srivastava · Lucknow, IN
• Satyawan Singh · Lucknow, IN

Key dates

• Filing date: Mar 29, 2000
• Grant date: May 25, 2004
• Expiry date: Mar 29, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/7023
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides novel inclusion complexes of highly potent opioid peptide of L-Tyrosyl-D-alanyl-glycyl-N-methylphenylalanyl-glycyl-isopropylamide with cyclodextrin, pharmaceutical preparations containing these inclusion complexes of L-Tyrosyl-D-alanyl-glycyl-N-methylphenylalanyl-glycyl-isopropylamide with cyclodextrin derivatives, the complexes being better soluble in water and having improved biopharmaceutical properties such as lesser toxicity, better analgesic action and non-addiction properties.