Thrombin inhibitors

US6740647B1 · kind B1 · utility

Assignee

• Abbott GmbH & Co. KG · DE

Inventors

• Dorit Baucke · Mannheim, DE
• Udo Lange · Ludwigshafen, DE
• Helmut Mack · Ludwigshafen, DE
• Werner Seitz · Plankstadt, DE
• Hans Wolfgang Höffken · Ludwigshafen, DE
• Wilfried Hornberger · Wiesbaden, DE

Key dates

• Filing date: Jun 21, 2000
• Grant date: May 25, 2004
• Expiry date: Jun 21, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel five-membered heterocyclic amidines, their preparation and use as competitive inhibitors of trypsin-like serine proteases, especially thrombin and kininogenases such as kallikrein. Pharmaceutical compositions which contain the compounds as active ingredients, and use of the compounds as thrombin inhibitors, anticoagulants and antiinflammatory agents.