4-[(8-ETHYNYL, 8-VINYL OR 8-ETHYNYL-METHYL)-6-CHROMANOYL]-BENZOIC AND 2-[4-[(8-ETHYNYL, 8-VINYL OR 8-ETHYNYL-METHYL)-6-CHROMANOYL]-PHENYL]-ACETIC ACID, THEIR ESTERS AND SALTS HAVING CYTOCHROME P450RAI INHIBITORY ACTIVITY

US6740676B2 · kind B2 · utility

Assignee

• Allergan, Inc. · US

Inventors

• Jayasree Vasudevan · Anaheim, US
• Liming Wang · Irvine, US
• Xiaoxia Liu · Lake Forest, US
• Kwok Yin Tsang · Irvine, US
• Yang-Dar Yuan · Irvine, US
• Roshantha Chandraratna · Laguna Hills, US

Key dates

• Filing date: Mar 19, 2002
• Grant date: May 25, 2004
• Expiry date: Mar 19, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of Formula 1: wherein the variables are defined in the specification have cytochrome P450RAI-1 and P450RAI-2 inhibitory activity, and are suitable for treatment of mammals with conditions which are treatable with retinoids, or which are controlled by or responsive to the organism's native retinoic acid. Formulations containing the compounds of the invention can also be co-administered with retinoids and/or Vitamin A to enhance or prolong the effects of medications containing retinoids, Vitamin A, or of the organism's native retinoic acid.