Estrogen mimetics lacking reproductive tract effects
US6743784B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Oct 15, 2001 |
| Grant date | Jun 1, 2004 |
| Priority date | — |
| Expiry date | Oct 15, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/386
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for treating symptoms, diseases and conditions in extra-reproductive tract tissues that are responsive to treatment with estrogen, using triarylethanes of formula (I) wherein R1 is —O(CH2)mR3 or —(CH2)nR3; wherein R3 is an anionic substituent; m is an integer from 1 to 4; and n is an integer from 0 to 4; and wherein R2 is either H or —OH. Each of R1 and R2 can be either meta or para to its respective phenyl ethyl linkage. Compounds having the formula (I) wherein R1 is —O(CH2)mR3 or —(CH2)nR3; R3 is an anionic substituent; m is 1, 2, 3 or 4; n is 0, 1, 2, 3 or 4; R2 is H or —OH; and wherein each of R1 and R2 is independently meta or para to its respective phenyl ethyl linkage are also provided, with the proviso that R2 is not para —OH when m is 1 and R3 is —COOH.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.