Indol-3-yl derivatives

US6743810B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Matthias Wiesner · Seeheim-Jugenheim, DE
• Simon Goodman
• Rudolf Gottschlich · Reinheim, DE

Key dates

• Filing date: Aug 9, 2002
• Grant date: Jun 1, 2004
• Expiry date: Aug 9, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Indol-3-yl derivatives of the general formula I in which A, B, X, R1, R2, R3, R4, R5, n and m are as defined in patent claim 1, and their physiologically acceptable salts or solvates are integrin inhibitors and can be employed for combating thromboses, cardiac infarction, coronary heart diseases, arteriosclerosis, inflammations, tumours, osteoporosis, rheumatic arthritis, macular degenerative disease, diabetic retinopathy, infections and restenosis after angioplasty or in pathological processes maintained or propagated by angiogenesis.