Hydrophilic polymers and methods of preparation
US6743880B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Apr 26, 2002 |
| Grant date | Jun 1, 2004 |
| Priority date | — |
| Expiry date | Apr 26, 2022 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/167
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a method for the preparation of hydrophilic water insoluble, gel-free copolymers of 2-hydroxyethyl methacrylate and at least one of acrylic acid or methacrylic acid, and 2-hydroxyethyl methacrylate, 4-hydroxybutyl acrylate and acrylic or methacrylic acid, where the copolymers are prepared in a solution of water and alcohol using monomeric 2-hydroxyethyl methacrylate containing ethylene glycol dimethacrylate impurities up to about 0.15% by weight and substantially in the absence of a chain transfer agent. The copolymers are convertible to water soluble copolymers by pH adjustment. The invention also provides a method for the preparation of a copolymer of 2-hydroxyethyl methacrylate and 4-hydroxybutyl acrylate, and a homopolymer of 2-hydroxyethyl methacrylate in a solution of water and either a monoalcohol or a polyhydric alcohol. The polymers are useful in topical skin applications, including use as cosmetic compositions, dermatological compositions, and flexible skin coatings, and as pressure sensitive adhesives.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.