4-aminobut-2-ynecarboxylic acid derivatives

US6743940B2 · kind B2 · utility

Assignee

• Ciba Specialty Chemicals Corporation · US

Inventors

• Werner Hölzl · Eschentzwiller, FR
• Wolfgang Haap · Bad Kötzting, DE
• Jurgen Koppold · Lörrach, DE
• Dietmar Ochs · Schopfheim, DE
• Karin Petzold · Fischingen, DE
• Marcel Schnyder · Wyhlen, DE

Key dates

• Filing date: Dec 13, 2001
• Grant date: Jun 1, 2004
• Expiry date: Feb 3, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C229/30
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

There are described 4-aminobut-2-ynecarboxylic acid derivatives of formula whereinR1 and R2 are each independently of the other hydrogen, C1-C20alkyl; C3-C12cycloalkyl; unsubstituted or C1-C5alkyl-, C3-C12cycloalkyl-, C1-C5alkoxy-, C3-C12cycloalkoxy-, halo-, oxo-, carboxy-, carboxy-C1-C7alkyl ester-, carboxy-C3-C12cycloalkyl ester-, cyano-, trifluoromethyl-, pentafluoroethyl-, amino-, N,N-mono- or di-C1-C20alkylamino- or nitro-substituted phenyl, phenyl-C1-C5alkyl, naphthyl and naphthyl-C1-C5alkyl; andR3 is C1-C20alkyl; C3-C12cycloalkyl.The compounds exhibit a pronounced activity against gram-positive and gram-negative bacteria, and also against yeasts and moulds.