Method for generating molecular arrays on porous surfaces
US6746104B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 25, 2001 |
| Grant date | Jun 8, 2004 |
| Priority date | — |
| Expiry date | Sep 25, 2021 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/2575
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides a unique and highly accurate method for generating molecular arrays of very high density on porous surfaces. The method involves the application of focused acoustic energy to each of a plurality of fluid-containing reservoirs to eject a small fluid droplet—on the order of 1 picoliter or less—from each reservoir to a site on a porous substrate surface. High density molecular arrays are provided as well, in which greater than about 62,500 molecular moieties, serving as array elements, are present on a porous surface. Biomolecular arrays that can be generated using focused acoustic ejection include oligonucleotide arrays and peptidic arrays.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.