L-lysine-producing corynebacteria and process for the preparation of L-lysine

US6746855B2 · kind B2 · utility

Assignees

• Dégussa-Hüls Aktiengesellschaft · DE
• Forschungszentrum Jülich GmbH · DE

Inventors

• Caroline Kreutzer · Melle, DE
• Stephan Hans · Osnabrück, DE
• Mechthild Rieping · Bielefeld, DE
• Bettina Mockel · Bielefeld, DE
• Walter Pfefferle · Bodenwerder, DE
• Lothar Eggeling · Jülich, DE
• Hermann Sahm · Jülich, DE
• Miroslav Patek · Praha, CZ

Key dates

• Filing date: Jan 8, 2003
• Grant date: Jun 8, 2004
• Expiry date: Jan 8, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P13/08
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention relates to L-lysine-producing strains of corynebacteria with enhanced lysE gene (lysine export carrier gene), in which strains additional genes chosen from the group comprising the dapA gene (dihydrodipicolinate synthase gene), the lysC gene (aspartate kinase gene), the dapB gene (dihydrodipicolinate reductase gene) and the pyc gene, but especially the dapA gene and the lysC gene (aspartate kinase gene), are enhanced and, in particular, over-expressed, and to a process for the preparation of L-lysine.