Pyrimidin-4-one compounds

US6747032B2 · kind B2 · utility

Assignee

• LES LABORATOIRES SERVIER · FR

Inventors

• Gilbert Lavielle · La Celle-Saint-Cloud, FR
• Thierry Dubuffet · L'Haÿ-les-Roses, FR
• Olivier Muller · Ennery, FR
• Mark Millan · Le Pecq, FR
• Anne Dekeyne · Le Puy-en-Velay, FR
• Mauricette Brocco · Paris, FR

Key dates

• Filing date: Apr 18, 2002
• Grant date: Jun 8, 2004
• Expiry date: Apr 18, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compound of formula (I): wherein:R1, R2, R3 and R4, which may be the same or different, each represent a hydrogen atom, a halogen atom or a group selected from alkyl, alkoxy, polyhaloalkyl, hydroxy, cyano, nitro and amino, or R1 with R2, R2 with R3, or R3 with R4, together with the carbon atoms carrying them, form an optionally substituted benzene ring or an optionally substituted heteroaromatic ring,X represents an oxygen atom or a methylene group,A represents an alkylene chain,  represents an optionally substituted, unsaturated, nitrogen-containing heterocycleand R5 represents an alkyl group,its enantiomers and diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid,a medicinal products containing the same are useful as a double &agr;2/5-HT2c antagonist.