Pyridine-based thyroid receptor ligands
US6747048B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 7, 2003 |
| Grant date | Jun 8, 2004 |
| Priority date | — |
| Expiry date | May 7, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D409/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel pyridine-based thyroid receptor ligands are provided which have the general formula I wherein:X is oxygen (—O—), sulfur (—S—), sulfoxide (—S(O)—), sulfonyl (—SO2—), CR8R8 or NR8;Y is —NR8, oxygen (—O—), —CH2— or sulfur (—S—);Z is a bond or substituted or unsubstituted C1-4 alkyl; andwherein the substituents are as described herein.In addition, a method is provided for preventing, inhibiting or treating diseases or disorders associated with metabolism dysfunction or which are dependent upon the expression of a T3 regulated gene, wherein a compound as described above is administered in a therapeutically effective amount.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.