Formulation for spray-drying large porous particles
US6749835B1 · kind B1 · utility
24Cited by
122References
50Claims
0Family size
Assignee
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Key dates
| Filing date | Aug 23, 2000 |
| Grant date | Jun 15, 2004 |
| Priority date | — |
| Expiry date | Aug 23, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/1617
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Particles having a tap density less than about 0.4 g/cm3 are formed by spray drying from a colloidal solution including a carboxylic acid or salt thereof, a phospholipid, a divalent salt and a solvent such as an aqueous-organic solvent. The colloidal solution can also include a therapeutic, prophylactic or diagnostic agent. Preferred carboxylic acids include at least two carboxyl groups. Preferred phospholipids include phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols, phophstidylserines, phosphatidylinositols and combinations thereof. The particles are suitable for pulmonary delivery.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.