Patent · US Expired

Subtle mitochondrial mutations as tumor markers

US6750021B2 · kind B2 · utility

1Cited by

5References

36Claims

0Family size

Assignee

THE JOHNS HOPKINS UNIVERSITY · US

Inventors

Kornelia Polyak · Baltimore, US
Bert Vogelstein · Baltimore, US
Kenneth W. Kinzler · Baltimore, US

Key dates

Filing date	Jan 24, 2002
Grant date	Jun 15, 2004
Priority date	—
Expiry date	Jan 24, 2022

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Q2600/156
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The accumulation of homoplasmic somatic mutations has been observed in the mitochondrial DNA of certain tumor cells. The presence or recurrence of a tumor can be detected by determining the presence of single basepair mutations in the mitochondrial genome from a cell sample of a patient.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.