Substituted amino acids as erythropoietin mimetics

US6750369B2 · kind B2 · utility

Assignee

• Ortho-McNeil Pharmaceutical, Inc. · US

Inventors

• Peter J. Connolly · New Providence, US
• Victor T. Bandurco · Bound Brook, US
• Steven K. Wetter · Flemington, US
• Sigmond Johnson · Flemington, US
• Jacqueline Bussolari · Skillman, US
• William V. Murray · Montgomery, US

Key dates

• Filing date: Aug 10, 2001
• Grant date: Jun 15, 2004
• Expiry date: Aug 10, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to a series of substituted amino acids of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention are small molecules which bind to the erythropoietin receptor and compete with the natural ligand for binding to this receptor.