Methods of separating FTC isomers and derivatives thereof

US6752929B1 · kind B1 · utility

Assignee

• Johnson Matthey Pharmaceutical Materials, Inc. · US

Inventors

• Salah A. Zahr · Acton, US
• David A. Swanson · Lexington, US
• Adel Moussa · Burlington, US
• Luning Han · Brookline, US

Key dates

• Filing date: Jul 12, 2002
• Grant date: Jun 22, 2004
• Expiry date: Jul 12, 2022

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a method of preparing enantiomers and diastereomers of a 2′,3′-dideoxy-5-fluoro-3′thiocytadine (FTC) or a derivative thereof as represented by the structural formula (I), wherein R is H, a substituted or unsubstituted organic acid radical, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted heteroarakyl group, a substituted or unsubstituted cycloalkyl group, a substituted or unsubstituted heterocycloalkyl group, a substituted or unsubstitued cycloalkylalkyl group, a substituted or unsubstituted heterocycloalkylalkyl group, a sugar or a protecting group.