Quinolinyl-piperidin-4-ylidene-methyl-benzamide derivatives for the treatment of pain

US6753335B2 · kind B2 · utility

Assignee

• ASTRAZENECA AB · SE

Inventors

• William Brown · Yorba Linda, US
• Christopher Walpole · Mont-Laurier, CA
• Zhongyong Wei · Beijing, CN

Key dates

• Filing date: Jan 21, 2003
• Grant date: Jun 22, 2004
• Expiry date: Jan 21, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of general formula I R1 is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, and triazolyl;where each R1 phenyl ring and R1 heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1-C6 alkyl, NO2, CF3, C1-C6 alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems;are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.