Preparation of drug particles using evaporation precipitation into aqueous solutions

US6756062B2 · kind B2 · utility

Assignee

• The Board of Regents of the University of Texas System · US

Inventors

• Keith P. Johnston · Austin, US
• Robert O. WILLIAMS, III · Austin, US
• Timothy J. Young · Bay City, US
• Xiaoxia Chen · Beijing, CN

Key dates

• Filing date: Mar 14, 2001
• Grant date: Jun 29, 2004
• Expiry date: Mar 14, 2021

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B82Y5/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method for preparing poorly water soluble drug particles is disclosed. The method comprises dissolving a drug in at least one organic solvent to form a drug/organic mixture, spraying the drug/organic mixture into an aqueous solution, and concurrently evaporating the organic solvent in the presence of the aqueous solution to form an aqueous dispersion of the drug particles. The resulting drug particles are in the nanometer to micrometer size range and show enhanced dissolution rates and reduced crystallinity when compared to the unprocessed drug.