Compounds useful as reversible inhibitors of cysteine proteases

US6756372B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim Pharmaceuticals, Inc. · US

Inventors

• Michel Jose Emmanuel · New Fairfield, US
• Weimin Liu · Sandy Hook, US
• Denice Spero · West Redding, US
• Sanxing Sun · Danbury, US
• David Thomson · Ridgefield, US
• Yancey David Ward · Sandy Hook, US

Key dates

• Filing date: Nov 2, 2001
• Grant date: Jun 29, 2004
• Expiry date: Nov 2, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (I), (II), (Ia) and (Ib) further defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds.