Methods for producing chiral chromones, chromanes, amino substituted chromanes and intermediates therefor

US6756403B2 · kind B2 · utility

Assignee

• ELI LILLY AND COMPANY · US

Inventors

• Barbara S. Briggs · Indianapolis, US
• James Kanter · South San Francisco, US
• John Mullins · Weaverville, US
• Gerd Ruhter · Hamburg, DE
• Uko Effiong Udodong · Indianapolis, US
• Milton J. Zmijewski, Jr. · Carmel, US
• Daniel E. Verral · Clinton, US

Key dates

• Filing date: Jul 11, 2003
• Grant date: Jun 29, 2004
• Expiry date: Jul 11, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D311/58
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are process steps and novel processes for producing chromane compositions enriched in at least one (2R or 2S) enantiomer, preferably chroman-2-yl carboxylic acid compounds and chroman-2-yl carboxylic acid esters which are intermediates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors. Further disclosed are enzymatic processes for resolving chiral intermediates or final products to provide desired enantiomers.