Culturing pancreatic stem cells having a specified, intermediate stage of development
US6759039B2 · kind B2 · utility
33Cited by
6References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 29, 2001 |
| Grant date | Jul 6, 2004 |
| Priority date | — |
| Expiry date | Jun 29, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/305
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
This invention relates to the discovery that an intermediate, differentiated stage of pancreatic stem cells exist that can be propagated in a stable manner in successive serial passaging while maintaining insulin production in response to glucose. These cells are advantageous in that they are both expandable and stable in culture and can driven to late stage development, i.e. prototype islet cells. This invention further provides for culturing techniques that select for these intermediate differentiated stage cells and selectively eliminates early or late stage pancreatic cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.