Patent · US Expired

Caspase homologue

US6759227B2 · kind B2 · utility

0Cited by

5References

2Claims

0Family size

Assignee

VLAAMS INTERUNIVERSITAIR INSTITUUT VOOR BIOTECHNOLOGIE VZW · BE

Inventors

Marc Van De Craen · Aalter, BE
Wim Declercq · Marke, BE
Peter Vandenabeele · Sint-Amandsberg, BE
Walter Fiers · Laarne, BE

Key dates

Filing date	Jan 17, 2001
Grant date	Jul 6, 2004
Priority date	—
Expiry date	Jun 5, 2021

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Caspases are cysteinyl aspartate-specific proteinases, many of which play a central role in apoptosis. This invention relates to the identification of a new murine caspase and its human homologue. The new molecules are most related to human/murine caspase-2 and human caspase-9 and possesses all the typical amino acid residues of the caspases involved in catalysis, including the QACRG box, and contains no or only a very short prodomain. Northern blot analysis revealed that mRNA expression of the new caspase is predominant in skin.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.