Patent · US Expired

Cycloocta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives

US6759405B2 · kind B2 · utility

2Cited by
15References
11Claims
0Family size

Assignee

Inventors

Key dates

Filing dateNov 2, 2001
Grant dateJul 6, 2004
Priority date—
Expiry dateMay 27, 2022

Classification

  • Technology area (CPC A)Human Necessities
  • CPC primaryA61P25/24
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

This invention provides compounds of formula I having the structure wherein: R1 and R2 are H, alkyl, cycloalkyl, alkoxy, halogen, fluorinated alkyl, —CN, —NH—SO2-alkyl, —SO2—NH-alkyl, alkyl amide, amino, alkylamino, dialkylamino, fluorinated, acyl, or aroyl; R3, R4 are H, alkyl, cycloalkyl or —CH2-cycloalkyl; R5 is H or alkyl; R6 is H or alkyl; and wherein the dashed line indicates an optional double bond; or a pharmaceutically acceptable salt thereof, as well as methods for using these compounds to treat central nervous system disorders, including obsessive-compulsive disorder, depression, anxiety, generalized anxiety disorder, schizophrenia, migraine, sleep disorders, eating disorders, obesity, epilepsy, and spinal cord injury.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.